My current research interests focus on identifying emerging challenges in the relatively young research field of epigenomics. In particular, I am interested in the interplay between methylome, transcriptome, and bacterial virulence / adaptation. My long term goal is to obtain a greater understanding of the key players and epigenetic pathways mediating gene expression alterations, and translate that information into more effective treatments for certain bacterial pathogens.
The epigenetic landscape is the bridge that connects the genome with its environment. I have taken a special interest in bacterial DNA methylation, and its multiple roles in cell defense against foreign DNA invasion, transcriptome remodelling, control of pathogen virulence, among others. I aim to 1) clarify the multiple functional roles of highly conserved methyltransferases; 2) understand their interplay with mobile genetic elements; and 3) explore the links between methylation and DNA topology.
I am lab head at the French National Sequencing Center - Genoscope.
We are integrating third generation long-read sequencing and comparative epigenomics to reveal the biological mechanisms central to microbial pathogenesis and adaptation.